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Healthy weight loss is usually 1 to 2 pounds per week; losing 10 pounds in one week is risky, should not be done often, and should only be attempted with the approval of your doctor. To lose 10 pounds in one week, you'll need to burn between 3,500 and 5,000 calories more than you consume each day by restricting your diet to small portions of nutritious yet low-calorie foods, and significantly increasing your aerobic exercise with interval training, sports, and other vigorous activities. This goal is both risky and difficult to achieve, but it can be done.